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Mushroom Health Directory

Mushroom Health Directory

Allergic Rhinitis (Hayfever)

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits. 

Clinical Trials

1. Anti-allergic constituents in the culture medium of Ganoderma lucidum. (I). Inhibitory effect of oleic acid on histamine release. Tasaka K, Akagi M, Miyoshi K, Mio M, Makino T. Agents Actions. 1988;23(3-4):153–156.

2. Anti-allergic constituents in the culture medium of Ganoderma lucidum. (II). The inhibitory effect of cyclooctasulfur on histamine release. Tasaka K, Mio M, Izushi K, Akagi M, Makino T. Agents Actions. 1988;23(3-4):157–160.

3. Effectiveness of Dp2 nasal therapy for Dp2- induced airway inflammation in mice: using oral Ganoderma lucidum as an immunomodulator. Liu YH, Tsai CF, Kao MC, Lai YL, Tsai JJ. J Microbiol Immunol Infect. 2003;36(4):236–242.

4. The use of Ganoderma lucidum (Reishi) in the management of Histamine-mediated allergic responses. Powell M. Nutritional Practitioner Magazine. 2004:26–30.

5. Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis. Mizutani N, Nabe T, Shimazu M, Yoshino S, Kohno S. Phytother Res. 2012;26(3):325–332.

6. Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum. Bhardwaj N, Katyal P, Sharma AK. Recent Pat Inflamm Allergy Drug Discov. 2014;8(2):104–117.

7. Chen, M.L., B.F.Lin. 2007b. Effects of triterpenoid-rich extracts of Ganoderma tsugae on airway hyperreactivity and Th2 responses in vivo. International Archives of Allergy and Immunology, 143(1):21-30.

Suggested Dose 

3g daily (triterpene rich extract)

Alzheimer’s Disease

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials focusing largely on its impacts on cognitive health with a large focus on nerve regeneration. 

Clinical Trials

1. Spelman, Kevin & Sutherland, Elizabeth & Bagade, Aravind. (2017). Neurological Activity of Lion’s mane (Hericium erinaceus). Journal of Restorative Medicine. 6. 19-26.10.14200/jrm.2017.6.0108.

Suggested Dose 

3-5g daily (fruiting body & mycelium biomass extract)

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits. 

Clinical Trials

1. Antagonizing β-amyloid peptide neurotoxicity of the anti-ageing fungus Ganoderma lucidum. Lai CS, Yu MS, Yuen WH, So KF, Zee SY, Chang RC. Brain Res. 2008;1190:215–224.

Suggested Dose 

3g daily (triterpene rich extract)

Anxiety

Mushroom

Lion's mane 

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials focusing largely on its impacts on cognitive health with a large focus on nerve regeneration. 

Clinical Trials

1. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Biomed Res. 2010;31(4):231–237.

Suggested Dose 

3-5g daily

Asthma

Mushroom

Cordyceps Sinensis 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist with respiratory conditions such as Asthma. 

Clinical Trials

1. Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review. Holliday J, Cleaver MP. Int J Med Mushrooms. 2008;10(3):219–234.

2. Effect of dongchong xiacao capsule on airway inflammation of asthmatic patients. Wang NQ, Jiang LD, Zhang XM, Li ZX. Zhongguo Zhongyao Zazhi. 2007;32(15):1566–1568.

3. Effects of fermented Cordyceps powder on pulmonary function in sensitized guinea pigs and airway inflammation in sensitized rats. Lin XX, Xie QM, Shen WH, Chen Y. Zhongguo Zhongyao Zazhi. 2001;26(9):622–625.

4. Effects of Cordyceps sinensis, Cordyceps militaris and their isolated compounds on ion transport in Calu-3 human airway epithelial cells. Yue GG, Lau CB, Fung K, Leung P, Ko W. J Ethnopharmacol. 2008;117(1):92–101.

5. Regulation of bronchoalveolar lavage fluids cell function by the immunomodulatory agents from Cordyceps sinensis. Kuo YC, Tsai WJ, Wang JY, Chang SC, Lin CY, Shiao MS. Life Sci. 2001;68(9):1067–1082.

Suggested Dose 

3g daily (mycelial biomass extract)

Mushroom 

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits. 

Clinical Trials

1. Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model. Lin JY, Chen ML, Chiang BL, Lin BF. Int Immunopharmacol. 2006;6(2):241–251.

2. Effects of triterpenoid-rich extracts of Ganoderma tsugae on airway hyperreactivity and Th2 responses in vivo. Chen ML, Lin BF. Int Arch Allergy Immunol. 2007;143(1):21–30.

Suggested Dose 

3g daily (triterpene rich extract)

 

Bacterial Infections

Mushroom

Lion's mane 

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials focusing largely on its impacts on cognitive health with a large focus on nerve regeneration. 

Clinical Trials
1. Anti-MRSA compounds of Hericium erinaceus (Bull.:Fr.) Pers. Kawagishi H. Int J Med Mushrooms. 2005;7(3):350.

Suggested Dose 

2.5-5g daily (mycelial biomass and fruiting body extract)

Mushroom

Reishi 

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits. 

Clinical Trials

1. Antibacterial activity of the bio-multidrug (Ganoderma lucidum) on Multidrug resistant Staphylococcus aureus (MRSA). Prasad Y, Wesely WEG. Advanced Biotech. 2008;10:9–16.

2. Naturally occurring medicinal mushroom-derived antimicrobials: a case-study using Lingzhi or Reishi Ganoderma lucidum (W. Curt.:Fr.) P. Karst. (higher Basidiomycetes). Karwa AS, Rai MK. Int J Med Mushrooms. 2012;14(5):481–490.

Suggested Dose 

2.5-5g daily (triterpene rich extract)

 

Benign Prostatic Hyperplasia (BPH)

Mushroom

Reishi


Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits. 

Clinical Trials

1. Anti-androgenic activities of Ganoderma lucidum. Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R. J Ethnopharmacol. 2005;102(1):107–112.

2. The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum. Liu J, Shimizu K, Konishi F, Kumamoto S, Kondo R. Bioorg Med Chem. 2007;15(14):4966–4972.

3. 5alpha-reductase inhibitory effect of triterpenoids isolated from Ganoderma lucidum. Liu J, Kurashiki K, Shimizu K, Kondo R. Biol Pharm Bull. 2006;29(2):392–395.

4. Ganoderma lucidum is an inhibitor of testosterone-induced prostatic hyperplasia in rats. Nahata A, Dixit VK. Andrologia. 2012;44(Suppl 1):160–174.

5. Effect of an extract of Ganoderma lucidum in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study. Noguchi M, Kakuma T, Tomiyasu K, Kurita Y, Kukihara H, Konishi F, Kumamoto S, Shimizu K, Kondo R, Matsuoka K. Asian J Androl. 2008;10(4):651–658.

6. Randomized clinical trial of an ethanol extract of Ganoderma lucidum in men with lower urinary tract symptoms. Noguchi M, Kakuma T, Tomiyasu K, Yamada A, Itoh K, Konishi F, Kumamoto S, Shimizu K, Kondo R, Matsuoka K. Asian J Androl. 2008;10(5):777–785.

Suggested Dose 

1-3g daily (triterpene rich extract)

 

Bladder Cancer

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

 

Clinical Trials

1. Inhibitory effect of Chinese herb medicine zhuling on urinary bladder cancer. An experimental and clinical study. Yang DA, Li SQ, Shi BY, Wang HW, Liu SG, Li YT, Zhou BM, Wang XX. Zhonghua Waike Zazhi, 1991;29(6):393–395, 399.

2. Prophylactic effects of zhuling and BCG on postoperative recurrence of bladder cancer. Yang DA, Li SQ, Li XT, Liu SG, Wang HW, Gao DJ. Zhonghua Waike Zazhi. 1994;32(7):433–434.

3. Prevention of postoperative recurrence of bladder cancer: a clinical study. Yang DA, Li SQ, Wang HW, Li XT, Liu SG, Han W, Hao JW, Zhang HB. Zhonghua Waike Zazhi. 1999;37(8):464–465.

4. Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine. Kurashige S, Akuzawa Y, Endo F. Immunopharmacol Immunotoxicol. 1997;19(2):175–183.

5. Effect of various natural products on growth of bladder cancer cells: two promising mushroom extracts. Konno S. Altern Med Rev. 2007;12(1):63–68.

6. Rajamahanty, S., B. Louie, C. O’Neill, M. Choudbury, S. Konno. 2009. Possible disease remission in patient with invasive bladder cancer with D-fraction regimen. International Journal of General Medicine 2:15-17.

Suggested Dose 

3-5g daily 

 

Brain Cancer

Mushroom

Maitake

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating as well as anti-tumor properties.

Clinical Trials

1. Maitake D-fraction: healing and preventive potential for cancer. Nanba H. J Orthomol Med. 1997;12(1):43–49.

Suggested Dose 

3-5g daily 

Mushroom

Chaga

Chaga (Inontus obliquus) is a sterile mass of highly concentrated mycelium. The mushroom has been used for centuries for improved gut and Immune health.

Clinical Trials

1. Betulinic acid: a new cytotoxic agent against malignant brain tumour cells. Fulda S, Jeremias I, Steiner HH, Pietsch T, Debatin KM. Int J Cancer. 1999;82(3):435–441.

2. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Cichewicz RH, Kouzi SA. Med Res Rev. 2004;24(1):90–114.

3. Betulinic acid, a natural compound with potent anticancer effects. Mullauer FB, Kessler JH, Medema JP. Anticancer Drugs. 2010;21(3):215–227.

Suggested Dose 

3-5g daily 

 

Breast Cancer

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties. 

Clinical Trials

1. Maitake D-fraction: healing and preventive potential for cancer. Nanba H. J Orthomol Med. 1997;12(1):43–49.

2. Deng, G., H. Lin, A. Seidman, M. Fornier, G,.D‘ Andrea,K. Wesa, S. Yeung et al. 2009. A phase I/II trial of a polysaccharide extract from Grifola frondose (Maitake mushroom) in breast cancer patients: immunological effects. Journal of Cancer Research & Clinical Oncology 135(9):1215-1221.

Suggested Dose 

3-5g daily 

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties. 

Clinical Trials

1. Immunochemotherapies versus chemotherapy as adjuvant treatment after curative resection of operable breast cancer. Iino Y, Yokoe T, Maemura M, Horiguchi J, Takei H, Ohwada S, Morishita Y. Anticancer Res. 1995;15(6B):2907–2911.

2. HLA antigen as predictive index for the outcome of breast cancer patients with adjuvant immunochemotherapy with PSK. Yokoe T, Iino Y, Takei H, Horiguchi J, Koibuchi Y, Maemura M, Ohwada S, Morishita Y. Anticancer Res. 1997;17(4A):2815–2818.

Suggested Dose 

3-5g daily 

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits. 

Clinical Trials

1. Potential role of medicinal mushrooms in breast cancer treatment: current knowledge and future perspectives. Petrova RD, Wasser SP; Mahajna JA, Denchev CM, Neva E. Int J Med Mushrooms. 2005;7(1–2):141–146.

2. Potential benefits of Ling Zhi or Reishi mushroom Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) to breast cancer patients. Chen AW, Seleen J. Int J Med Mushrooms. 2007;9(1):29–38.

Suggested Dose 

3-5g daily 

 

Cardiovascular Health

Mushroom

Reishi


Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials
1.  A phase I/II study of ling zhi mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) extract in patients with coronary heart disease. Gao Y, Chen G, Dai X, Ye J, Zhou S. Int J Med Mushrooms. 2004;6(4):327–334.

2. The triterpenoids of Ganoderma tsugae prevent stress-induced myocardial injury in mice. Kuok QY, Yeh CY, Su BC, Hsu PL, Ni H, Liu MY, Mo FE. Mol Nutr Food Res. 2013;57(10):1892–1896.

3. Chu, T.T.W, I.F.F. Benzie, CW.K. Lam, B.S.P. Fok, K.K.C. Lee, B. Tomlinson. 2012. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): Results of controlled human intervention trials. British journal of nutrition 107(7):1017-1027.

Suggested Dose 

3g daily 

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Medicinal value of the caterpillar fungi species of the genus Cordyceps (Fr.) Link (Ascomycetes). A review. Holliday J, Cleaver M. Int J Med Mushrooms. 2008;10(3):219–234.

2. Cardiovascular protection and antioxidant activity of the extracts from the mycelia of Cordyceps sinensis act partially via adenosine receptors. Yan XF, Zhang ZM, Yao HY, Guan Y, Zhu JP, Zhang LH, Jia YL, Wang RW. Phytother Res. 2013;27(11):1597–1604.

3. Cordycepin, 3′-deoxyadenosine, prevents rat hearts from ischemia/reperfusion injury via activation of Akt/GSK-3β/p70S6K signaling pathway and HO-1 expression. Park ES, Kang DH, Yang MK, Kang JC, Jang YC, Park JS, Kim SK, Shin HS. Cardiovasc Toxicol. 2014;14(1):1–9.

4. Zhu, JS., et al. “The Scientific Rediscovery of a precious ancient Chinese herbal regimen: cordyceps sinensis: Part II. ”Journal of alternative and complementary medicine (New York, N.Y.) vol.4, no.4, 1998, pp. 429-57.

Suggested Dose 

3g daily 

Mushroom

Tremella (Snow Fungus)

Tremella, also known as the beauty mushroom, is a medicinal mushroom mostly known for its skin health and cognitive boosting benefits.

Clinical Trials

1. Research advances in primary biological effects of Tremella polysaccharides. Chen FF, Cai DL. Zhong Xi Yi Jie He Xue Bao. 2008;6(8):862–866.

Suggested Dose 

3g daily 

 

Cervical Cancer

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Coriolus versicolor supplementation in HPV patients. [Poster]. Couto JS, da Silva DP. 20th European Congress of Obstetrics and Gynaecology, 2008

Suggested Dose 

3g daily 

 

Cognitive Health Mind and Memory Support

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Brandalise F, Cesaroni V, Gregori A. et al. Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber-CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice. Evid Based Complement Alternat Med. 2017;2017:3864340.doi:10.1155/2017/3864340

2. Rossi P, Cesaroni V, Brandalise F, Occinegro A, Ratto D, Perrucci F, Lanaia V, Girometta C, Orru G, Savino E. Dietary Supplementation of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatical Memory in Wild-Type Mice. Int J med Mushrooms. 2018;20(5):485-494.doi:10.1615/IntJedMedMushrooms.2018026241.

3. Saitsu, Y., A. Nishide, K. Kikushima, K. Shimizu, K. Ohnuki. 2019. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomedicial Research 40(4): 125-131.

Suggested Dose 

3-5g daily 

Mushroom

Tremella (Snow Fungus)

Tremella, also known as the beauty mushroom, is a medicinal mushroom mostly known for its skin health and cognitive boosting benefits.

Clinical Trials

1. Kim, J.H., H.C. Ha, M.S. Lee et al. 2007. Effect of Tramella fuciformis on the neurite outgrowth of PC 12h cells and the improvement of memory in rats. Biological and Pharmacology Bulletin 30(4):708-714.

2. Park, H.J., H.S. Shim, Y.H. Ahn, K.S. Kim et al. 2012. Tramella fuciformes enhances the neurite outgrowth of PC12 cells and restores trimethyltin-induced impairment of memory in rats via activation of CREB transcription and cholinergic systems. Behavioural Brain Research 229(1): 82-9-.

Suggested Dose 

3-5g daily 

 

Chronic Fatigue Syndrome

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties. 

Clinical Trials

1. A formal analysis of cytokine networks in Chronic Fatigue Syndrome. Broderick G, Fuite J, Kreitz A, Vernon SD, Klimas N, Fletcher MA. Brain Behav Immun. 2010;24(7):1209–1217.

2. Plasma cytokines in women with chronic fatigue syndrome. Fletcher MA, Zeng XR, Barnes Z, Levis S, Klimas NG. J Transl Med. 2009;7:96.

3. High levels of type 2 cytokine-producing cells in chronic fatigue syndrome. Skowera A, Cleare A, Blair D, Bevis L, Wessely SC, Peakman M. Clin Exp Immunol. 2004;135(2): 294–302.

4. Pioneering work at Breakspear Hospital on Coriolus supplementation for CFIDS/ME patients. Mycology News. 2000;1(4):4.

Suggested Dose 

3g daily 

Mushroom 

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Tang, Wenbo & gao, Yihuai & Chen, Guoliang & Gao, He & Dai, Xihu & Ye, Jinxian & Chan, Eli & Huang, Min & Zhou, Shufeng. (2005). A Randomized, Double-Blind and Placebo-Controlled Study of a Ganoderma lucidium Polysaccharide Extract Neurasthenia. Journal of medicinal food. 8. 53-8. 10.1089/jmf.2005.8.53.

Suggested Dose 

3-5g daily 

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Zhu, J S., et al. “The Scientific Rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: Part II.” Journal of Alternative and Complemntary Medicine (New York, N.Y), vol. 4, no.4 1998, pp. 429-57

2. Lin B, Li S. Cordyceps as an Herbal Drug. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis;2001

3. Song J., Y. Wang, M. Teng, G. Cai, H. Xu, H. Guo, Y. Liu, D. Wang, and L. Teng. 2015. Studies on the anti-fatigue activities of Cordyceps militaris fruit body extract in mouse model. Evidence Based Complementary Alternative Medicine doi: 10, 1155/2015/174616.

Suggested Dose 

1-3g daily 

 

Colorectal Cancer

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials. Sakamoto J, Morita S, Oba K, Matsui T, Kobayashi M, Nakazato H, Ohashi Y. Cancer Immunol Immunother. 2006;55(4):404–411.

2. Mitomi, T.,S. Tsuchiya, N. Iljima, K. Aso et al. 1992. Randomized, controlled study on adjuvant immunochemotheraoy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunotherapy for Cancer of Colon and Rectum (Kanagawa). Diseases of the colon and rectum 35(2):123-130.

3. Ohwada, S., T. Ogawa, F. Makita, Y. Tanahsi, T. Ohya, N. Tomizawa et al. 2006. Beneficial effects of protein-bound polysaccharide K plus tegafur/uracil in patients with stage II or III colorectal cancer: analysis of immunological parameters. Oncology Reports 15: 861:868. #

4. Sakamoto, J., S. Morito, K. Oba, Matsui, M. Kobayashi, H. Nakazato, Y. Ohashi. 2006. Meta-analysis group of the Japanese Society for Cancer of the colon rectum. Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally, randomized controlled clinical trials. Cancer Immunology, Immunotherapy 55(4):404-411. 

Suggested Dose 

3g daily

Mushroom

Reishi


Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Monitoring of immune responses to a herbal immunomodulator in patients with advanced colorectal cancer. Chen X, Hu ZP, Yang XX, Huang M, Gao Y, Tang W, Chan SY, Dai X, Ye J, Ho PC, Duan W, Yang HY, Zhu YZ, Zhou SF. Int Immunopharmacol. 2006;6(3):499–508.

2. Immune responses to water-soluble ling zhi mushroom Ganoderma lucidum (W.Curt.:Fr.) P. Karst. Polysaccharides in patients with advanced colorectal cancer. Huang M; Gao YH; Tang W; Dai X; Gao H; Chen GL, Ye JX, Chan EL, Zhou SF. Int J Med Mushrooms. 2006;7(4):525–538. 7.

3. A water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia suppresses azoxymethane-induction of colon cancers in male F344 rats. Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H. Oncol Rep. 2003;10(2):375–379.

Suggested Dose 

5g daily

 

Dementia

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Phytother Res. 2009;23(3):367-72.

2. The anti-dementia effect of Lion’s mane mushroom (Hericium erinaceus) and its clinical application. Kawagishi H, Zhuang C, Shnidman E. Townsend Letter for Doctors and Patients 249. 2004.

Suggested Dose 

3-5g daily 

 

Depression

Mushroom 

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Biomed Res. 2010;31(4):231–237.

2. Brandalise F, Cesaroni V, Gregori A, et al. Dietary Supplementation of Hericium erinaceus Increases Mossy Fiber – CA3 Hippocampal Neurotransmission and Recognition Memory in Wild-Type Mice. Evid Based Complement Alternat Med. 2017;2017:3864340, doi:10.1155/2017/3864340

3. Chong, P.S., M.L. Fung, K.H. Wong, L.W. Lim. 2019. Therapeutic potential of Hericium erinaceus for depressive disorders. International Journal of Molecular Science 21(1).doi: 10.3390/ijms21010163.

4. Inanga, K. 2014. Marked improvement of neurocognitive impairment after treatment with compounds from Hericium erinaceum: a case study of recurrent depressive disorder. Personalized Medicine Universe 3: 46-48.

Suggested Dose 

3-5g daily 

Mushroom 

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Antidepressant-like effects of a water-soluble extract from the culture medium of Ganoderma lucidum mycelia in rats. Matsuzaki H, Shimizu Y, Iwata N, Kamiuchi S, Suzuki F, Iizuka H, Hibino Y, Okazaki M. BMC Complement Altern Med. 2013;13:370.

Suggested Dose 

2-5g daily 

 

Diabetes

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Hypoglycemic effect of extract of Hericium erinaceus. Wang JC, Hu SH, Wang JT, Chen KS, Chia YC. J Sci Food Agric. 2005;85(4):641–646.

2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of hericium erinaceus in experimental diabetic rates. BMC Complement Altern Med. 2013;13:253. Published 2013 Oct 3. Doi: 10.1186/1472-6882-13-253

3. Yi Z, Shao-Long Y, Ai-Hong W, et al. Protective Effect of Ethanol Extracts of Hericium erinaceus onAlloxan-Induced Diabetic Neuropathic Pain in rats. Ecid Based Complement Alternat med. 2015;2015:595480. Doi:10.1155/2015/595480

Suggested Dose 

3-5g daily 

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. CordyMax Cs-4 improves glucose metabolism and increases insulin sensitivity in normal rats. Zhao CS, Yin WT, Wang JY, Zhang Y, Yu H, Cooper R, Smidt C, Zhu JS. J Altern Complement Med. 2002;8(3):309–314.

2. Lo HC, Hsu TH, Tu ST, Lin KC. Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotoxcin. Am J Chin Med. 2006;34 (5):819-32

3. Shi B, Wang Z, Jin H, Chen YW, Wang Q, Qian, Y. Immunoregulatory Cordyceps sinensis increases regulatory T cells to Th17 cel ratio and delays diabetes in NOD mice. Int Immunopharmacol. 2009 May; 9(5):582-6

4. Kai Z, Yongjian, L. Sheng G, Yu L. Effect of Dongchongxiacao (Cordyceps) therapy on contrast induced nephropathy in patients with type 2 diabetes and renal insufficiency undergoing coronary angiography. J Tradit Chin Med. 2015 Aug;35(4):422-7

5. Zhu, J S., et al. “Scientific Rediscovery of a precocious ancient Chinese herbal regimen: Cordyceps sinensis: part II.” Journal of Alternative and Complementary Medicine (new York, N.;Y.), vol. 4, no.4, 1998, pp. 429-57.

6. The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin. Lo HC, Tu ST, Lin KC, Lin SC. Life Sci. 2004;74(23):2897–2908.

Suggested Dose 

3-5g daily 

Mushroom:

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. A phase I/II study of Ling Zhi mushroom Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) extract in patients with type II Diabetes Mellitus. Gao Y, Lan J, Dai X, Ye J, Zhou S. Int J Med Mushrooms. 2004;6(1):327–334.

2. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. Tang W, Gao Y, Chen G, Gao H, Dai X, Ye J, Chan E, Huang M, Zhou S. J Med Food. 2005;8(1):53–58.

Suggested Dose 

5g daily

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). Kubo K, Aoki H, Nanba H. Biol Pharm Bull. 1994;17(8):1106–1110.

2. Maitake (Grifola frondosa) improve glucose tolerance of experimental diabetic rats. Horio H, Ohtsuru M. J Nutr Sci Vitaminol. 2001;47(1):57–63.

3. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Mol Cell Biochem. 2002;237(1–2):129–136.

4. Horio H, Ohtsuru M. Maitake (Grifola frandosa) improve glucose tolereance of experimental diabetic rats, J Nutr Sci Vitaminol (Tokyo)

Suggested Dose 

3-5g daily

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Xian HM, Che H, Qin Y, Yanf F, meng SY, Li XG, bai YL, Wang LH. Corilous versicolor aqueous extract ameliorates insulin resistance with Pl3K/Akt and p38 MAPK signaling pathways involved in diabetic skeletal muscle. Phythoer Res. 2018 Mar;32(3):551-560.doi: 10.1002/ptr.6007.

2. Want Y, Li H, Li Y, Zhao Y, Xiong F, Liu Y, Xue H, yang Z, Ni S, Sahil A, Che H, Wang L, Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiatic fibrosis and NLRP3 inflammasome activation. Phytother Res. 2019 Oct;33 (10):2737-2748.doi: 10.1002/ptr.6448.Epub 2019 Jul 23.

Suggested Dose 

3g daily

Mushroom

Tremella (Snow Fungus)

Tremella, also known as the beauty mushroom, is a medicinal mushroom mostly known for its skin health and cognitive boosting benefits. 

Clinical Trials

1. Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumii in ob/ob mice. Cho EJ, Hwang HJ, Kim SW, Oh JY, Baek YM, Choi JW, Bae SH, Yun JW. Appl Microbiol Biotechnol. 2007;75(6):1257–1265.

Suggested Dose 

3-5g daily 

 

Endurance & Stamina

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind placebo-controlled trial. J altern complement med.2010 May; 16(5):585-90.doi:10.1089/acm.2009-0226.

Suggested Dose 

3g daily

 

Epilepsy

Mushroom 

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Intervention effects of Ganoderma lucidum spores on epileptiform discharge hippocampal neurons and expression of neurotrophin-4 and N-cadherin. Wang SQ, Li XJ, Zhou S, Sun DX, Wang H, Cheng PF, Ma XR, Liu L, Liu JX, Wang FF, Liang YF, Wu JM. PLoS One. 2013;8(4):e61687.

2. Anticonvulsant and neuroprotective effects of oligosaccharides from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (higher Basidiomycetes). Tello I, Campos-Pena V, Montiel E, Rodriguez V, Aguirre-Moreno A, Leon-Rivera I, Del Rio-Portilla F, Herrera-Ruiz M, Villeda-Hernandez J. Int J Med Mushrooms. 2013;15(6):555–568.

3. Anti-epileptic effect of Ganoderma lucidum polysaccharides by inhibition of intracellular calcium accumulation and stimulation of expression of CaMKII α in epileptic hippocampal neurons. Wang SQ, Li XJ, Qiu HB, Jiang ZM, Simon M, Ma XR, Liu L, Liu JX, Wang FF, Liang YF, Wu JM, Di WH, Zhou S. PLoS One. 2014;9(7):e102161.

Suggested Dose 

3-5g daily

 

Erectile Dysfunction

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Regulatory mechanism of Cordyceps sinensis mycellium on mouse Leydig cell steroidogenesis. Hsu CC, Tsai SJ, Huang YL, Huang BM. FEBS Lett. 2003;543(1–3):140–143.

2. The in vivo effect of Cordyceps sinensis mycelium on plasma corticosterone level in male mouse. Leu SF, Chien CH, Tseng CY, Kuo YM, Huang BM. Biol Pharm Bull. 2005;28(9):1722–1725.

3. Regulation of steroidogenesis by Cordyceps sinensis mycelium extracted fractions with (hCG) treatment in mouse Leydig cells. Wong KL, So EC, Chen CC, Wu RS, Huang BM. Arch Androl. 2007;53(2):75–77.

4. Jiraungkoorskkul, K. & W. Jiraungkoorskul. 2016. Review of naturpathy of medicinal mushrooms, Ophiocordyceps sinensis, in sexual dysfunction. Pharmacognosy Review 10(9): 1-5.

Suggested Dose 

3g daily 

 

Exercise-induced Immune Suppression

Mushroom 

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Immunomodulatory effect of Ganoderma lucidum polysaccharides (GLP) on long-term heavy-load exercising mice. Shi Y, Cai D, Wang X, Liu X. Int J Vitam Nutr Res. 2012;82(6):383–390.

Suggested Dose 

3g daily 

 

Gastric Cancer

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer. Oba K, Teramukai S, Kobayashi M, Matsui T, Kodera Y, Sakamoto J. Cancer Immunol Immunother. 2007;56(6):905–911.

2. Nakazato, H., A. Koike, S. Saji, N. Ogawa, J. Sakamoto. 1994. Efficacy of immunochemotherapy as adjuvant treatment after curative resection of gastric cancer. Study group of immunochemotherapy with PSK for gastric cancer. Lancet 343 (8906):1122-1126.

Suggested Dose 

3-5g daily 

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

Li, G., K. Yu, F. Li, K.P. Xu, J. Li, S.J. He et al. 2014. Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers. Journal of Ethnopharacology 153: 521-530.

Suggested Dose 

3-5g daily 

 

Gastric Ulcers

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Gastroprotective effects of Lion’s Mane mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) extract against ethanol-induced ulcer in rats. Wong JY, Abdulla MA, Raman J, Phan CW, Kuppusamy UR, Golbabapour S, Vikineswary S. Evid Based Complement Alternat Med. 2013;2013:492976.

2. In vitro anti-Helicobacter pylori effects of medicinal mushroom extracts, with special emphasis on the Lion’s Mane mushroom, Hericium erinaceus (higher Basidiomycetes). Shang X, Tan Q, Liu R, Yu K, Li P, Zhao GP. Int J Med Mushrooms. 2013;15(2):165–174.

3. A double-blind study of effectiveness of Hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. Xu CP, Liu WW, Liu FX, Chen SS, Liao FQ, Xu Z, Jiang LG, Wang CA, Lu XH. Chin Med J (Engl). 1985;98(6):455–456.

4. Cytoprotective effects of Hericium erinaceus on gastric mucosa in rats. Yu CG, Xu ZM, Zhu QK, Zhang ZH, Chen ZR, Sun CH, Zhang YF, Wang N. Chin J Gastroenterol. 1999:4(2):93–96.

5. Effect of culinary-medicinal Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae), on Ethanol-induced gastric ulcers in rats. Abdulla MA, Noor S, Vikineswary S, Abdullah N, Wong KH, Ali HM. Int J Med Mushrooms. 2008;10(4):325–330.

Suggested Dose 

3-5g daily 

 

Hepatitis

Mushroom:

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. A phase I/II study of a Ganoderma lucidum (Curt.: Fr.) P. Karst. (Ling Zhi, Reishi Mushroom) extract in patients with chronic Hepatitis В. Gao YH, Zhou SF, Chen GL, Dai XH, Ye JX, Gao H. Int J Med Mushrooms. 2002;4(4):321–328.

2. Anti-hepatitis B activities of ganoderic acid from Ganoderma lucidum. Li YQ, Wang SF. Biotechnol Lett. 2006;28(11): 837–841.

3. Gao, Y.H., S.F. Zhou, G.L. Chen, X.H. Dai, J.X. Ye, H. Gao. 2002a. A phase 1/11 study of Ganoderma lucidum extract in patients with chronic hepatitis B. International Journal of Medicinal Mushrooms 4(4):321-7.

Suggested Dose 

3g daily 

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Short-term curative effect of cultured Cordyceps sinensis (Berk.) Sacc. Mycelia in chronic hepatitis B. Zhou LM, Yang YZ, Xu YM, Zhu QY, Ma ZL, Zhu TR, Ge XY, Gao JD. Zhongguo Zhongyao Zazhi. 1990;15(1):53–55, 65.

2. Effects of Cordyceps polysaccharides in patients with chronic hepatitis C. Ma X, Qiu DK, J Xu, Zeng MD. Shijie Huaren Xiaohua Zazhi. 1998;6(7):582–584.

3. Effects of Cordyceps sinensis on T lymphocyte subsets and hepato-fibrosis in patients with chronic hepatitis B. Gong HY, Wang KQ, Tang SG. Hunan Yike Daxue Xue Bao. 2000;25(3):248–250.

4. Zhu , J.S., et al. “The Scientitifc Redisovery of a Precious Ancient Chinese Herbal Regimen: Cordyceps Sinensis: Part II.” Journal of Alternative and Complementary Medicine (New York,, N.Y.), vol.4 no. 4, 1988, pp. 429-57

5. Wang, X.B., Y.Y.Jiang C.Y. Zhao. 2012. Clinical research of xinganbao capsule on the treatment of chronic hepatitis B liver fibrosis. Zhongguo Zhong Xi Yi Jie He Za Zhi (article in Chinese) 32(3):325-328

Suggested Dose 

3g daily 

Mushroom

Chaga

Chaga (Inontus obliquus) is a sterile mass of highly concentrated mycelium. The mushroom has been used for centuries for improved gut and Immune health.

Clinical Trials

1. Shibnev, V.A. & Mishin, Dmitriy & Garaev. Timur & Finogenova, N.P. Botikov, A.G. & Deryabin, Petr. (2011). Antiviral Activity of Inontus Obliquus Fungus Extract towards Infection Caused by Hepatitis C Virus in Cell Cultures. Bulletin of experimental biology and medicine. 151.612-4.10.1007/s10517-011-1395-8

Suggested Dose 

5g daily 

 

Herpes

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Treatment of recurrent genital herpes with PSK. Kawana T. Proceedings of the International Symposium on Pharmacological and Clinical Approaches to Herpes Viruses and Virus Chemotherapy. Oiso, Japan, Sept. 10-13, 1984. Kono R, Nakajima A (Eds). Amsterdam : Excerpta Medica, 1985. pp. 271–272.

2. In vitro inactivation of herpes simplex virus by a biological response modifier, PSK. Monma Y, Kawana T, Shimizu F. Antiviral Res. 1997;35(3):131–138.

Suggested Dose 

3-5g daily 

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa. Gu CQ, Li JW, Chao F, Jin M, Wang XW, Shen ZQ. Antiviral Res. 2007;75(3):250–257.

 

HIV

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Phosphorothioate and cordycepin analogues of 2’, 5’- oligoadenylate: Inhibition of Human Immunodeficiency Virus type 1 reverse transcriptase and infection in vitro. Montefiori DC, Sobol RW Jr, Li SW, Reichenbach NL, Suhadolnik RJ, Charubala R, Pfleiderer W, Modliszewski A, Robinson WE Jr, Mitchell WM. Proc Natl Acad Sci USA. 1989;86(18):7191–7194.

2. Synthesis, characterization, and biological activity of monomeric and trimeric cordycepin-cholesterol conjugates and inhibition of HIV-1 replication. Wasner M, Henderson EE, Suhadolnik RJ, Pfleiderer W. Helv Chim Acta. 1994;77(7):1757–1761.

Suggested Dose 

3-5g daily 

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Polysaccharopeptide from the Turkey tail fungus Trametes versicolor (L.:Fr.) Pilát inhibits Human Immunodeficiency Virus type 1 reverse transciptase and protease. Ng TB, Wang HX, Wan DCC. Int J Med Mushrooms. 2006;8(1):39–43.

2. Polysaccharopeptide from Coriolus versicolor has potential for use against Human Immunodeficiency Virus type 1 infection. Collins RA, Ng TB. Life Sci. 1997;60(25):383–387.

3. A biological response modifier, PSK, inhibits reverse transcriptase in vitro. Hirose K, Hakozaki M, Kakuchi J, Matsunaga K, Yoshikumi C, Takahashi M, Tochikura TS, Yamamoto N. Biochem Biophys Res Commun. 1987;149(2):562–567.

4. The effectiveness of Coriolus versicolor supplementation in the treatment of Kaposi sarcoma in HIV+Patients. [Poster]. Tindall J, Clegg E. Presented at the 10th International Congress of Mucosal Immunology in Amsterdam, June 28th – July 1st, 1999.

5. The clinical use of Coriolus versicolor supplementation in HIV+ patients and the impact on CD4 count and viral load. [Poster]. Pfeiffer M. Presented at the III International Symposium on Mushroom Nutrition in Milan on Saturday, March 10th, 2001.

Suggested Dose 

3-5g daily 

Mushroom 

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

7. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. el-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N, Shimotohno K, Kawahata T, Otake T. Phytochemistry. 1998;49(6):1651–1657.

8. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Min BS, Nakamura N, Miyashiro H, Bae KW, Hattori M. Chem Pharm Bull. 1998;46(10):1607–1612.

Suggested Dose 

3-5g daily 

Mushroom

Chaga

Chaga (Inontus obliquus) is a sterile mass of highly concentrated mycelium. The mushroom has been used for centuries for improved gut and Immune health.

Clinical Trials

1. Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Cichewicz RH, Kouzi SA. Med Res Rev. 2004;24(1):90–114.

2. Betulinic acid derivatives as Human Immunodeficiency Virus type 2 (HIV-2) inhibitors. Dang Z, Lai W, Qian K, Ho P, Lee KH, Chen CH, Huang L. J Med Chem. 2009;52(23):7887–7891.

Suggested Dose 

3-5g daily 

 

HPV

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Coriolus versicolor supplementation in HPV patients. [Poster]. Couto JS, da Silva DP. 20th European Congress of Obstetrics and Gynaecology. March 7th, 2008.

Suggested Dose 

3g daily 

 

Hypercholesterolaemia

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Cholesterol-lowering effects of maitake (Grifola frondosa) fiber, shiitake (Lentinus edodes) fiber, and enokitake (Flammulina velutipes) fiber in rats. Fukushima M, Ohashi T, Fujiwara Y, Sonoyama K, Nakano M. Exp Biol Med (Maywood). 2001;226(8):758–765.

2. Maitake extracts and their therapeutic potential – A Review. Mayell M. Alt Med Rev. 2001;6(1):48–60.

3. Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms. Lo YC, Lin SY, Ulziijargal E, Chen SY, Chien RC, Tzou YJ, Mau JL. Int J Med Mushrooms. 2012;14(4):357–363.

4. Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms. Lin SY, Chen YK, Yu HT, Barseghyan GS, Asatiani MD, Wasser SP, Mau JL. Int J Med Mushrooms. 2013;15(3):315–323.

Suggested Dose 

3-5g daily 

Mushroom 

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex-vivo, and in hamsters and minipigs. Berger A, Rein D, Kratky E, Monnard I, Piguet-Welsch C, Hauser J, Mace K, Niederberger P. Lipids Health Dis. 2004;3:2.

Suggested Dose 

3-5g daily 

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Shiitake (Lentinus edodes) Wasser SP. Encyclopedia of Dietary Supplements. 2005. pp. 653–664.

2. Quantitative analysis of eritadenine in ‘Shii-take’ mushroom and other edible fungi. Saito M, Yamashita T, Kaneda T. Eiyo to Shokuryo (J Jap Soc Food Nutr). 1975;28(9):503–505.

3. Quantification of the bioactive compound eritadenine in selected strains of shiitake mushroom (Lentinus edodes). Enman J, Rova U, Berglund KA. J Agric Food Chem. 2007;55(4):1177–1180.

4. Production of the bioactive compound eritadenine by submerged cultivation of shiitake (Lentinus edodes) mycelia. Enman J, Hodge D, Berglund K.A, Rova U. J Agric Food Chem. 2008;56(8):2609–2612.

 

Suggested Dose 

3-5g daily 

 

Hypertension

Mushroom 

Reishi


Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Dietary effect of Ganoderma lucidum mushroom on blood pressure and lipid levels in spontaneously hypertensive rats (SHR). Kabir Y, Kimura S, Tamura T. J Nutr Sci Vitaminol. 1988;34(4):433–438.

2. Effect of Ganoderma lucidum on the quality and functionality of Korean traditional rice wine, yakju. Kim JH, Lee DH, Lee SH, Choi SY, Lee JS. J Biosci Bioeng. 2004;97(1):24–28.

3. Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Lee SY, Rhee HM. Chem Pharm Bull. 1990;38(5):1359–1364.

Suggested Dose 

3g daily (triterpene rich)

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Talpur NA, Echard BW, Fan AY, Jaffari O, Bagchi D, Preuss HG. Mol Cell Biochem. 2002;237(1-2):129–136.

2. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). Kabir Y, Kimura S. J Nutr Sci Vitaminol. 1989;35(1):91–94.

3. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. Kabir Y, Yamaguchi M, Kimura S. J Nutr Sci Vitaminol. 1987;33(5):341–346.

Suggested Dose 

3g daily

 

Infertility

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Cordyceps sinensis mycelium activates PKA and PKC signal pathways to stimulate steroidogenesis in MA-10 mouse Leydig tumour cells. Chen YC, Huang YL, Huang BM. Int J Biochem Cell Biol. 2005;37(1):214–223.

2. Upregulation of steroidogenic enzymes and ovarian 17beta-estradiol in human granulosa-lutein cells by Cordyceps sinensis mycelium. Huang BM, Hsiao KY, Chuang PC, Wu MH, Pan HA, Tsai SJ. Biol Reprod. 2004;70(5):1358–1364.

3. In vivo stimulatory effect of Cordyceps sinensis mycelium and its fractions on reproductive functions in male mouse. Huang YL, Leu SF, Liu BC, Sheu CC, Huang BM. Life Sci. 2004;75(9):1051–1062.

4. Improvement of sperm production in subfertile boars by Cordyceps militaris supplement. Lin WH, Tsai MT, Chen YS, Hou RC, Hung HF, Li CH, Wang HK, Lai MN, Jeng KC. Am J Chin Med. 2007;35(4):631–641.

5. Immune-Related Female Infertility. Wing T. TCM Kongress Rothenburg, 2012.

Suggested Dose 

3g daily

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with firstline clomiphene citrate. Chen JT, Tominaga K, Sato Y, Anzai H, Matsuoka R. J Altern Complement Med. 2010;16(12):1295–1299.

Suggested Dose 

3g daily

 

Inflammatory Bowel Disease

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Grifola frondosa water extract alleviates intestinal inflammation by suppressing TNF-alpha production and its signaling. Lee JS, Park SY, Thapa D, Choi MK, Chung IM, Park YJ, Yong CS, Choi HG, Kim JA. Exp Mol Med. 2010;42(2):143–154.

Suggested Dose 

3g daily

Mushroom 

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid. Hanaoka R, Ueno Y, Tanaka S, Nagai K, Onitake T, Yoshioka K, Chayama K. Scand J Immunol. 2011;74(5):454–462.

2. Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice. Sliva D, Loganathan J, Jiang J, Jedinak A, Lamb JG, Terry C, Baldridge LA, Adamec J, Sandusky GE, Dudhgaonkar S. PLoS One. 2012;7(10):e47873.

Suggested Dose 

3g daily

Mushroom

Chaga

Chaga (Inontus obliquus) is a sterile mass of highly concentrated mycelium. The mushroom has been used for centuries for improved gut and Immune health.

Clinical Trials

1. Orally administered aqueous extract of Inonotus obliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice. Mishra SK, Kang JH, Kim DK, Oh SH, Kim MK. J Ethnopharmacol. 2012;143(2):524–532.

2. Chaga mushroom extract inhibits oxidative DNA damage in lymphocytes of patients with inflammatory bowel disease. Najafzadeh M, Reynolds .D, Baumgartner A, Jerwood D, Anderson D. Biofactors. 2007;31(3-4):191–200.

Suggested Dose 

3g daily

 

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Intestinal anti-inflammatory activity of lentinan: influence on IL-8 and TNFR1 expression in intestinal epithelial cells. Nishitani Y, Zhang L, Yoshida M, Azuma T, Kanazawa K, Hashimoto T, Mizuno M. PLoS One. 2013;8(4):e62441.

Suggested Dose 

3g daily 

 

Influenza

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. In vivo anti-influenza virus activity of an immunomodulatory acidic polysaccharide isolated from Cordyceps militaris grown on germinated soybeans. Ohta Y, Lee JB, Hayashi K, Fujita A, Park DK, Hayashi T. J Agric Food Chem. 2007;55(25):10194–10199.

Suggested Dose 

3g daily

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Inhibitory effect of TNF-α produced by macrophages stimulated with Grifola frondosa extract (ME) on the growth of influenza A/Aichi/2/68 virus in MDCK cells. Obi N, Hayashi K, Miyahara T, Shimada Y, Terasawa K, Watanabe M, Takeyama M, Obi R, Ochiai H. Am J Chin Med. 2008;36(6):1171–1183.

Suggested Dose 

3g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Antiviral and interferon-inducing activities of a new peptidomannan, KS-2, extracted from culture mycelia of Lentinus edodes. Suzuki F, Suzuki C, Shimomura E, Maeda H, Fujii T, Ishida N. J Antibiot. 1979;32(12):1336–1345.

Suggested Dose 

3-5g daily 

 

Insomnia

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Sleep-promoting effects of Ganoderma extracts in rats: comparison between long-term and acute administrations. Honda K, Komoda Y, Inoué S. Tokyo Ika Shika Daigaku Iyo Kizai Kenkyusho Hokoku. 1988;22:77–82.

2. The hypnotic and sedative actions of the spores of Ganoderma lucidum (Curt.: Fr.) P. Karst. (Aphyllophoromycetideae) in mice. Yu L, Wei H. Int J Med Mushrooms. 2000;2(4):323–328.

3. Ganoderma lucidum: a potent pharmacological macrofungus. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Curr Pharm Biotechnol. 2009;10(8):717–742.

4. Extract of Ganoderma lucidum potentiates pentobarbital-induced sleep via a GABAergic mechanis. Chu QP, Wang LE, Cui XY, Fu HZ, Lin ZB, Lin SQ, Zhang YH. Pharmacol Biochem Behav. 2007;86(4):693–698.

Cui XY, Cui SY,Zhang J, Wang ZJ, Yu B, Sheng ZF, Zhang XQ, Zhang YH. Extract Ganoderma lucidum prolongs sleep in rats. J Ethnopharmacol. 2012 Feb 15;139(3):796-800.doi:10.1016/j.jep.2011.12.020

Suggested Dose 

3g daily

 

Inflammation

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Mori K, Ouchi K, Hirasawa N. The Anti-Inflammatory Effects of Lion’s Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes) in a Coculture System of 3T3-L1 Adipocytes and RAW264 Macrophages. Int J Med Mushrooms. 2015;17 (7): 609-18.

Suggested Dose 

3g daily

 

Kidney Health

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

Sun, T.L., W.L. Dong, G.H. Jiang, J.B. Yang, J.H. Liu, L.J. Zhao, P.L. Ma. 2019. Cordyceps militaris improves chronic kidney disease by affecting TLR/NF-B redox signaling pathway. Oxidative Medicine and Cellular Longevity 7850863.

Suggested Dose 

3g daily

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Qin M, Geng Y, Lu Z, Xu H, Shi JS, Xu X, Xu ZH. Anti-Inflammatory Effects of Ethanol Extract of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with ulcerative colitis. Int J Med Mushrooms. 2016;18(3):227-34.doi:10.1615/IntJMedMushrooms.v18.i3.50.

2. Wong JY, Abdulla MA, Ramen J, et al. Gastroprotective Effects of Lion’s mane Mushroom Hericium erinaceus (Bull.:FR.)Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats. Evid Based Complement Alternat Med. 2013;2013:492976, doi: 10.1155.2013/492976

Suggested Dose 

3g daily

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Lee JS, park Sy, Thapa D, Choi MK, Chung IM, Park YJ, Yong CS, Choi HG, Kim JA. Grifola frondose water extract alleviates intestinal inflammation by supressing TNF-alpha production and its signaling. Exp Mol Med. 2010 Feb 28:42(2):143-54. Doi: 10.3858/emm.2010.42.016.

Suggested Dose 

3g daily

 

Leukaemia

Mushroom 

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Coriolus versicolor (Yunzhi) extract attenuates growth of human leukaemia xenografts and induces apoptosis through the mitochondrial pathway. Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan H, Lau CB. Oncol Rep. 2006;16(3):609-16.

2. Cytotoxic activities of Coriolus versicolor (Yunzhi) extract on human leukaemia and lymphoma cells by induction of apoptosis. Lau CB, Ho CY, Kim CF, Leung KN, Fung KP, Tse TF, Chan HH, Chow MS. Life Sci. 2004;75(7):797–808.

Suggested Dose 

3-5g daily

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties. 

Clinical Trials

1. Can Maitake MD-fraction aid cancer patients? Kodama N, Komuta K, Nanba H. Alt Med Rev. 2002;7(3):236–239.

Suggested Dose 

3-5g daily

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Cordyceps sinensis mycelium extract induces human premyelocytic leukaemia cell apoptosis through mitochondrion pathway. Zhang QX, Wu JY. Exp Biol Med. 2007;232(1):52–57.

2. Effect of Cordyceps sinensis on the proliferation and differentiation of human leukemic U937 cells. Chen YJ, Shiao MS, Lee SS, Wang SY. Life Sci. 1997;60(25):2349–2359.

3. Chou S.M., W.J. Lai, T.W. Hong, J.Y. Lai J., S.H. Tsai, Y.H. Chen, S.H, et al. 2014. Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells.Phytomedicine 21(12):1516-1524.

Suggested Dose 

3-5g daily

 

Liver Cancer

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Maitake D-fraction: healing and preventive potential for cancer. Nanba H. J Orthomolecular Med. 1997;12(1):43–49.

Suggested Dose 

4-6g daily

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1.Triterpene-enriched extracts from Ganoderma lucidum inhibit growth of hepatoma cells via suppressing protein kinase C, activating mitogen-activated protein kinases and G2-phase cell cycle arrest. Lin SB, Li CH, Lee SS, Kan LS. Life Sci. 2003;72(21):2381–2390.

2. Ganoderic acid produced from submerged culture of Ganoderma lucidum induces cell cycle arrest and cytotoxicity in human hepatoma cell line BEL7402. Yang HL. Biotechnol Lett. 2005;27(12):835–838.

3. Antitumour activity of the sporoderm-broken germinating spores of Ganoderma lucidum. Liu X, Yuan JP, Chung CK, Chen XJ. Cancer Lett. 2002;182(2):155–161.

4. Ganoderiol F, a Ganoderma triterpene, induces senescence in hepatoma HepG2 cells. Chang UM, Li CH, Lin LI, Huang CP, Kan LS, Lin SB. Life Sci. 2006;79(12):1129–1139.

5. The anti-invasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain. Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC. Mol Nutr Food Res. 2007;51(12):1472–1477.

6. Inhibitory effects of Ganoderma lucidum on tumourigenesis and metastasis of human hepatoma cells in cells and animal models. Weng .J, Chau CF, Yen GC, Liao JW, Chen DH, Chen KD. J Agric Food Chem. 2009;57(11):5049–5057.

Suggested Dose 

3-5g daily (triterpene rich)

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Cordyceps sinensis increases the expression of major histocompatibility complex class II antigens on human hepatoma cell line HA22T/VGH cells. Chiu JH, Ju CH, Wu LH, Lui WY, Wu CW, Shiao MS, Hong CY. Am J Chin Med. 1998;26(2):159–170.

Suggested Dose 

3-5g daily

Mushroom

Chaga

Chaga (Inontus obliquus) is a sterile mass of highly concentrated mycelium. The mushroom has been used for centuries for improved gut and Immune health.

Clinical Trials

1. Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells. Youn MJ, Kim JK, Park SY, Kim Y, Kim SJ, Lee JS, Chai KY, Kim HJ, Cui MX, So HS, Kim KY, Park R. World J Gastroenterol. 2008;14(4):511–517.

 

Liver Damage

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Cordyceps sinensis supplementation in alcohol-induced liver steatosis. Santos C. Mycology News. 2004;1(9):[2–6].

2. Inhibitive effect of Cordyceps sinensis on experimental hepatic fibrosis and its possible mechanism. Liu YK, Shen W. World J Gastroenterol. 2003;9(3):529–533.

Suggested Dose 

3g daily

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum. Kim DH, Shim SB, Kim NJ, Jang IS. Biol Pharm Bull. 1999;22(2):162–164.

2. Evaluation of the hepatic and renal-protective effects of Ganoderma lucidum in mice. Shieh YH, Liu CF, Huang YK, Yang JY, Wu IL, Lin CH, Li SC. Am J Chin Med. 2001;29(3-4):501–507.

3. Hepatoprotective role of Ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB. World J Gastroenterol. 2002;8(4):728–733.

4. Post-treatment of Ganoderma lucidum reduced liver fibrosis induced by thioacetamide in mice. Wu YW, Fang HL, Lin WC. Phytother Res. 2010;24(4):494–499.

5. Wang, G.-J., Huang, Y.-j., Chen, D.-H and Lin, Y.-L. (2019), ganoderma lucidium extract attenuates the proliferaqtion of hepatic stellate cells by blocking the PDGF receptor. Phytother. Res., 23:833-839. Doi:10.1002/ptr.2687

Suggested Dose 

3-5g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Protection against D-galactosamine-induced acute liver injury by oral administration of extracts from Lentinus edodes mycelia. Watanabe A, Kobayashi M, Hayashi S, Kodama D, Isoda K, Kondoh M, Kawase M, Tamesada M, Yagi K. Biol Pharm Bull. 2006;29(8):1651–1654.

Suggested Dose 

3-5g daily 

Mushroom

Tremella (Snow Fungus)

Tremella, also known as the beauty mushroom, is a medicinal mushroom mostly known for its skin health and cognitive boosting benefits.

Clinical Trials

1. Guo, Z., X.H. Tan. 2005. The curative effect of Tramella polysaccharide enteric-coated capsules in preventing and treating acute liver injury after blood tumor chemotherapy. Infect Dis Inf 18:71265.

Suggested Dose 

3-5g daily 

 

Lung Cancer

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Maitake D-fraction: healing and preventive potential for cancer. Nanba H. J Orthomolecular Med. 1997;12(1):43–49.

Suggested Dose 

3-5g daily

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Bizarro A., I.C. Ferreria, M. Sokovic, L.J. van Griensven, D. Sousa, et al. 2015. Cordyceps militaris (L.) link fruiting body reduces the growth of a non-small cell lung cancel cell line by increasing cellular levels of p53 and p21. Molecules 20(8):13927-13940.

Suggested Dose 

3-5g daily

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Coriolus versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer. Tsang KW, Lam CL, Yan C, Mak JC, Ooi GC, Ho JC, Lam B, Man R, Sham JS, Lam WK. Respir Med. 2003;97(6):618–624.

2. Catita, J. 2000. The use of Coriolus-MRL supplementation lung cancer patients undergoing radiotherapy. Mycology News 1(4):3-4.

3. Hayakawa, K., N. Mitsuhashi, Y. Saito, M. Takahashi, S. Katano, K. Shiojima, M. Furuta, H. Niibe. 1993. Effect of krestin (PSK) as adjuvant treatment on the prognosis after radical radiotherapy in patients with non-small cell lung cancer. Anticancer Research 13(5C):1815-1820.

4. Tsang, K.W., C.L. Lam, C. Yan, J.C. Mak et al. 2003. Corilos versicolor polysaccharide peptide slows progression of advanced non-small cell lung cancer. Respiratory Medicine 97(6):618-624.

Suggested Dose 

3-5g daily

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Gao, Y., W. Tang, X. Dai, H. Gao, G. Chen et al. 2005. Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. Journal of Medicinal Food 8(2):159-168.

Suggested Dose 

3-5g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Zhang, Y., M. Zhang, Y. Jiang, X.L. Li, He et al. 2018. Lentinan as an immunotherapeutic for treating lung cancer: A review of 12 years clinical studies in China. Journal of Cancer Research and Clinical Oncology 144(11):2177-2186.

Suggested Dose 

3-5g daily 

 

Lymphoma

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1. Maruyama S, Akasaka T, Yamada K, Tachibana H. Biomed Pharmacother. 2009;63(6):409–412.

2. Protein-bound polysaccharide K induced apoptosis of the human Burkitt lymphoma cell line, Namalwa. Hattori TS, Komatsu N, Shichijo S, Itoh K. Biomed Pharmacother. 2004;58(4):226–230.

3. Potentiation of T cell immunity against radiation-leukaemia-virus-induced lymphoma by polysaccharide K. Yefenof E, Einat E, Klein E. Cancer Immunol Immunother. 1991;34(2):133–137.

4. Prophylactic intervention in radiation-leukaemia-virus-induced murine lymphoma by the biological response modifier polysaccharide K. Yefenof E, Gafanovitch I, Oron E, Bar M, Klein E. Cancer Immunol Immunother. 1995;41(6):389–396.

Suggested Dose 

3-5g daily

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Ganoderma lucidum causes apoptosis in leukaemia, lymphoma and multiple myeloma cells. Müller CI, Kumagai T, O’Kelly J, Seeram NP, Heber D, Koeffler HP. Leuk Res. 2006;30(7):841–848.

2. Cytotoxic action of Ganoderma lucidum on interleukin-3 dependent lymphoma DA-1 cells: involvement of apoptosisproteins. Calviño E, Pajuelo L, de Eribe Casas JA, Manjón JL, Tejedor M.C, Herráez A, Alonso MD, Diez JC. Phytother Res. 2010;25(1):25-32.

3. Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)? Cheuk W, Chan JK, Nuovo G, Chan MK, Fok M. Int J Surg Pathol. 2007;15(2):180–186.

Suggested Dose 

3-5g daily

 

Meniere’s Syndrome

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Nutritional mushroom treatment in Meniere’s Disease with Coriolus versicolor: a rationale for therapeutic intervention in neuroinflammation and antineurodegeneration. Scuto M, Di Mauro P, Ontario ML, Amato C, Modafferi S, Ciavardelli D, Trovato Salinaro A, Maiolino L, Calabrese V. Int J Mol Sci, 2019;21(1):284.

Suggested Dose 

3-5g daily

 

Multiple Sclerosis

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. The influence of Hericium erinaceus extract on myelination process in vitro. Kolotushkina EV, Moldavan MG, Voronin KY, Skibo GG. Fiziol Zh. 2003;49(1):38–45.

Suggested Dose 

5g daily

 

Nerve Damage

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Functional recovery enhancement following injury to rodent peroneal nerve by Lion’s Mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae). Wong KH, Naidu M, David RP, Abdulla MA, Abdullah N, Kuppusamy UR, Vikineswary S. Int J Med Mushrooms. 2009;11(3):225–236.

2. Neuronal health – can culinary and medicinal mushrooms help? Vikineswary S, Wong KH, Naidu M, David P. J Tradit Complement Med. 2013;3(1):62–68.

3. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Phan CW, David P, Naidu M, Wong KH, Vikineswary S. Crit Rev Biotechnol. 2015:35(3):355–368.

4. Spelman, Kevin & Sutherland, Elizabeth & Bagade, Aravind. (2017). Neurological Activity of Lion’s Mane (Hericium erinaceus). Journal of Restorative Medicine. 6.19-26.10.14200/jrm.2017.6.0108.

Suggested Dose 

3-5g daily

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Primary study on proteomics about Ganoderma lucidium spores promoting survival and axon regeneration of injured spinal motor neurons in rats. Zhang W, Zeng YS, Wang Y, Liu W, Cheng JJ, Chen SJ. Zhong Xi Yi Jie He Xue Bao. 2006;4(3):298–302.

2. Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3. Phan CW, David P, Naidu M, Wong KH, Vikineswary S. BMC Complement Altern Med. 2013;13:261.

3. potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Phan CW, David P, Naidu M, Wong KH, Vikineswary S. Crit Rev Biotechnol. 2015:35(3):355–368.

Suggested Dose 

3-5g daily

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Phan CW, David P, Naidu M, Wong KH, Vikineswary S. Crit Rev Biotechnol. 2015:35(3):355–368.

2. Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3. Phan CW, David P, Naidu M, Wong KH, Vikineswary S. BMC Complement Altern Med. 2013;13:261.

Suggested Dose 

3-5g daily

Mushroom

Maitake 

1. Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Phan CW, David P, Naidu M, Wong KH, Vikineswary S. Crit Rev Biotechnol. 2015:35(3):355–368.

2. Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3. Phan CW, David P, Naidu M, Wong KH, Vikineswary S. BMC Complement Altern Med. 2013;13:261.

Suggested Dose 

3-5g daily

Mushroom

Tremella (Snow Fungus)

Tremella, also known as the beauty mushroom, is a medicinal mushroom mostly known for its skin health and cognitive boosting benefits.

Clinical Trials

1. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Phan CW, David P, Naidu M, Wong KH, Vikineswary S. Crit Rev Biotechnol. 2015:35(3):355–368.

Suggested Dose 

3-5g daily 

 

Ovarian Cancer

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties

Clinical Trials

1. Effects of cimetidine and PSK on interleukin-2 production by PBL in patients with advanced ovarian carcinoma during the course of chemotherapy. Kikuchi Y, Kizawa I, Oomori K, Iwano I, Kita T, Miyauchi M, Kato K. Nippon Sanka Fujinka Gakkai Zasshi. 1987;39(11):1987–1992.

2. Effects of PSK on interleukin-2 production by peripheral lymphocytes of patients with advanced ovarian carcinoma during chemotherapy. Kikuchi Y, Kizawa I, Oomori K, Iwano I, Kita T, Kato K. Jpn J Cancer Res. 1988;79(1):125–130.

3. Antitumour effect of PSK and its combined effect with CDDP on ovarian serous adenocarcinoma-bearing nude mice. Ishii K, Kita T, Hirata J, Tode T, Kikuchi Y, Nagata I. Nippon Sanka Fujinka Gakkai Zasshi. 1993;45(4):333–339.

4. Enhancement of anti-cancer activity of cisdiaminedichloroplatinum by the protein-bound polysaccharide of Coriolus versicolor QUEL (PS-K) in vitro. Kobayashi Y, Kariya K, Saigenji K, Nakamura K. Cancer Biother. 1994;9(4):351–358.

Suggested Dose 

3-5g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Shimizu, Y., K. Hasumi T. Chen. 1989. Successful treatment of a patient with recurrent ovarian cancer by lentinan combined with intra-arterial 5FU. Japanese Journal of Cancer Research 24(3):647-651.

Suggested Dose 

3-5g daily 

 

Pancreatic Cancer

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties.

Clinical Trials

1. Two cases of unresectable pancreatic cancer responding to combined chemotherapy with cisplatin, PSK and UFT. Sohma M, Kitagawa T, Okano S, Utsumi M, Mutoh E, Takeda S, Kanda M, Suzuki Y, Okamura K, Namiki M. Gan To Kagaku Ryoho. 1987;14(6 Pt 1):1926–1929.

2. PSK-mediated NF-kappaB inhibition augments docetaxelinduced apoptosis in human pancreatic cancer cells NOR-P1. Zhang H, Morisaki T, Nakahara C, Matsunaga H, Sato N, Nagumo F, Tadano J, Katano M. Oncogene. 2003;22(14):2088–2096.

3. Rosehdahl, A.H., C. Sun, D. Wu, R. Anderson. 2012. Polysaccharide-K (PSK) increases p21 (WAF/Cip1) and promotes apoptosis in pancreatic cancer cells. Pancreatology 12(6):467-74.

Suggested Dose 

3-5g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Shimizu, K., S. Watanabe, Sh. Watanabe, K. Matsuda, T. Suga. S. Nakazawa, K. Shiroratu. 2009. Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer. Hepatogastroenerology 56:240-244.

Suggested Dose 

3-5g daily 

 

Parasitic Infections

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum. Oluba OM, Olusola AO, Eidangbe GO, Babatola LJ, Onyeneke EC. Cholesterol. 2012;2012:536396.

2. Antimalarial and hepatoprotective effects of crude ethanolic extract of Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W.Curt.:Fr.)P.Karst. (higher Basidiomycetes), in Plasmodium berghei-infected mice. Oluba OM, Olusola AO, Fagbohunka BS, Onyeneke EC. Int J Med Mushrooms. 2012;14(5):459–4661

Suggested Dose 

3-5g daily

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. The effects of cordycepin on malaria parasites. Trigg PI, Gutteridge WE, Williamson J. Trans R Soc Trop Med Hyg. 1971;65(4):514–520.

2. Structures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponica. Isaka M, Tantichareon M, Thebtaranonth Y. J Org Chem. 2001;66(14):4803–4808.

Suggested Dose 

3-5g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses. Zhou LD, Zhang QH, Zhang Y, Liu J, Cao YM. Int Immunopharmacol. 2009;9(4):455–462.

Suggested Dose 

3-5g daily 

 

Parkinson’s Disease

Mushroom

Lion's Mane

Lion's Mane (Hericium erinaceus) is a coral-like shaped mushroom containing a variety of beta-glucans, cell wall polymores and diterpenes such as erinacines which give the mushroom its medicinal properties. The mushroom is one of the most clinically studied mushrooms with trials showing the mushrooms ability to assist with cognitive function. 

Clinical Trials

1. Spelman, Kevin & Sutherland, Elizabeth & Bagade, Aravind. (2017). Neurological Activity of Lion’s mane (Hericium erinaceus). Journal of Restorative Medicine. 6. 19-26.10.14200/jrm.2017.6.0108.

2. Lee, K.F., S.Y. Tung, C.C. Teng, C.H. Shen et al. 2020. Post-treatment with erinacine A, a derived diterpenoid of H. erinaceus, attenuates neurotoxicity in MPTP model of Parkinson’s disease. Antioxidants (Basel) 9(2):137.

Suggested Dose 

3-5g daily

 

Polycystic Ovary Syndrome PCOS

Mushroom

Maitake 

1. Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with Polycystic Ovary Syndrome: a possible monotherapy and a combination therapy after failure with first-line Clomiphene Citrate. Chen J, Tominaga K, Sato Y, Anzai H, Matsuoka R. J Alt Comp Med. 2010;16(12):1295–1299.

Suggested Dose 

3g daily

 

Prostate Cancer

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Pharmacological values of medicinal mushrooms for prostate cancer therapy: the case of Ganoderma lucidum. Mahajna J, Dotan N, Zaidman BZ, Petrova RD, Wasser SP. Nutr Cancer. 2009;61(1):16–26.

2. Ganoderma lucidum (Reishi) in cancer treatment. Sliva D. Integr Cancer Ther. 2003;2(4):358–364.

3. Androgen receptor-dependent and -independent mechanisms mediate Ganoderma lucidum activities in LNCaP prostate cancer cells. Zaidman BZ, Wasser SP, Nevo E, Mahajna J. Int J Oncol. 2007;31(4):959–967.

4. Anti-androgen effects of extracts and compounds from Ganoderma lucidum. Liu J, Tamura S, Kurashiki K, Shimizu K, Noda K, Konishi F, Kumamoto S, Kondo R. Chem Biodivers. 2009;6(2):231–243.

5. The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum. Liu J, Shimizu K, Konishi F, Kumamoto S, Kondo R. Bioorg Med Chem. 2007;15(14):4966–4972.

6. Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells. Stanley G, Harvey K, Slivova V, Jiang J, Sliva D. Biochem Biophys Res Commun. 2005;330(1):46–52.

7. Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3. Jiang J, Slivova V, Valachovicova T, Harvey K, Sliva D. Int J Oncol. 2004;24(5):1093–1099.

8. Biologic activity of spores and dried powder from Ganoderma lucidum for the inhibition of highly invasive human breast and prostate cancer cells. Sliva D, Sedlak M, Slivova V, Valachovicova T, Lloyd FP Jr, Ho NW. J Altern Complement Med. 2003;9(4):491–497.

9. Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R. Bioorg Med Chem Lett. 2009;19(8):2154–2157.

10. Anti-androgenic activities of Ganoderma lucidum. Fujita R, Liu J, Shimizu K, Konishi F, Noda K, Kumamoto S, Ueda C, Tajiri H, Kaneko S, Suimi Y, Kondo R. J Ethnopharmacol. 2005;102(1):107–112.

11. Huang, S.Y., G.J. Huang, H.C. Wu, M.C. Kao, W.C. Huang. 2018. Ganoderma tsugae inhibits the SREPB-1/AR axis leading to suppression of cell growth and activation of apoptosis in prostate cancer cells. Molecules 23(10):2539.

Suggested Dose 

3g daily

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide). Fullerton SA, Samadi AA, Tortorelis DG, Choudhury MS, Mallouh C, Tazaki H, Konno S. Mol Urol. 2000;4(1):7–13.

Suggested Dose 

3g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Huang, J.Q., A. M. Mondul, S.J. Weinstein, A. Derkach et al. 2019. Prospective serum metabolomic profiling of lethal prostate cancer. International Journal of Cancer 145(12):3231-3243.

2. White, R.W., R.M. hackman, S.E. Soares, L.A. Beckett, B.X. Sun. 2002. Effects of a mushroom mycelium extract on the treatment of prostate cancer. Urology 60(4):640-644.

Suggested Dose 

3-5g daily 

 

Psoriasis

Mushroom

Chaga

Chaga (Inontus obliquus) is a sterile mass of highly concentrated mycelium. The mushroom has been used for centuries for improved gut and Immune health.

Clinical Trials

1. Dosychev, E.A., VN, Bystrova.1973. Treatment of psoriasis using Chaga fungus preparation. Vestnik Dermatologii I Venerologii 47(5):79-83.

Suggested Dose 

3g daily

 

Renal Health

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Medicinal value of the caterpillar fungi species of the genus Cordyceps. Holliday J, Cleaver M. Int J Med Mushrooms. 2008;10(3):219–234.

Suggested Dose 

3g daily

 

Rheumatoid Arthritis

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Anti-inflammatory and anti-tumour-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum. Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E, Suzuki T, Kimura Y. Chem Biodivers. 2007;4(2):224–231.

2. Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum. Dudhgaonkar S, Thyagarajan A, Sliva D. Int Immunopharmacol. 2009;9(11):1272–1280.

3. Bao YX, Wong CK, Li EK, Tam LS, leung PC, Yin YB Lam CW. Immunomodulatory effects of lingzhi and san-miao-san supplementation on patients with rheumatoid arthritis. Immunopharmacol Immunotoxicol. 2006;28(2):197-200

Suggested Dose 

3g daily

 

Skin Cancer (Melanoma)

Mushroom

Maitake 

Maitake (Grifola frondosa) is a polymore mushroom known for its nutrient dense content and immune-activating properties.

Clinical Trials

1. Maitake D-fraction. Apoptosis inducer and immune enhancer. Konno S. Altern Complement Ther. 2001;7(2):102–107.

Suggested Dose 

3-5g daily

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Effects of Cordyceps sinensis on natural killer activity and colony formation of B16 melanoma. Xu RH, Peng XE, Chen GZ, Chen GL. Chin Med J (Engl). 1992;105(2):97–101.

2. Inhibitory effects of ethyl acetate extract of Cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL/6 mice. Wu JY, Zhang QX, Leung PH. Phytomedicine. 2007;14(1):43–49.

Suggested Dose 

3-5g daily

Mushroom

Turkey Tail

Turkey Tail (Trametes versicolor) is one of the most well-documented mushrooms with research and clinical trials focusing on its immune activating properties as well as cancer fighting abilities. 

Clinical Trials

1. Antimetastatic effect of PSK, a protein-bound polysaccharide, against the B16-BL6 mouse melanoma. Matsunaga K, Ohhara M, Oguchi Y, Iijima H, Kobayashi H. Invasion Metastasis. 1996;16(1):27–38.

Suggested Dose 

3-5g daily

Mushroom

Chaga

Chaga (Inontus obliquus) is a sterile mass of highly concentrated mycelium. The mushroom has been used for centuries for improved gut and Immune health.

Clinical Trials

1. Potential anticancer properties of the water extract of Inonotus obliquus by induction of apoptosis in melanoma B16-F10 cells. Youn MJ, Kim JK, Park SY, Kim Y, Park C, Kim ES, Park KI, So HS, Park R. J Ethnopharmacol. 2009;121(2):221–228.

Suggested Dose 

3-5g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. 5. Selective induction of apoptosis in murine skin carcinoma cells (CH72) by an ethanol extract of Lentinula edodes. Gu Y.H, Belury M.A. Cancer Lett. 2005;220(1):21–28.

Suggested Dose 

3-5g daily 

 

Skin Health

Mushroom

Chaga

Chaga (Inontus obliquus) is a sterile mass of highly concentrated mycelium. The mushroom has been used for centuries for improved gut and Immune health.

Clinical Trials

1. Yan ZF, Yang Y, Tian FH, Mao XX, Li Y, Li CT. Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells. Evid Based Complement Alternat Med. 2014;2014:259836. doi: 10.1155/2014/259836. Epub 2014 Aug 13. PMID: 25197307; PMCID: PMC4145793.

2. Yun JS, Pahk JW, Lee JS, Shin WC, Lee SY, Hong EK. Inonotus obliquus protects against oxidative stress-induced apoptosis and premature senescence. Mol Cells. 2011 May;31(5):423-9. doi: 10.1007/s10059-011-0256-7. Epub 2011 Feb 22. PMID: 21359681; PMCID: PMC3887607.

Suggested Dose 

3-5g daily

Mushroom 

Shiitake

Shiitake is one of the most well known mushrooms. Besides being used in culinary dishes it also contains amazing medicinal properties.

Clinical Trials

1. Taofiq O, Heleno SA, Calhelha RC, Alves MJ, Barros L, Barreiro MF, González-Paramás AM, Ferreira IC. Development of Mushroom-Based Cosmeceutical Formulations with Anti-Inflammatory, Anti-Tyrosinase, Antioxidant, and Antibacterial Properties. Molecules. 2016 Oct 14;21(10):1372. doi: 10.3390/molecules21101372. PMID: 27754433; PMCID: PMC6274557.

2. Avinash J, Vinay S, Jha K, Das D, Goutham BS, Kumar G. The Unexplored Anticaries Potential of Shiitake Mushroom. Pharmacogn Rev. 2016 Jul-Dec;10(20):100-104. doi: 10.4103/0973-7847.194039. PMID: 28082791; PMCID: PMC5214552.

Suggested Dose 

3-5g daily 

Mushroom

Cordyceps 

Cordyceps is one of the most popular medicinal mushrooms with clinical trials focusing on the mushrooms ability to assist in a variety of areas such as respiratory conditions and immune activation.

Clinical Trials

1. Park JM, Lee JS, Lee KR, Ha SJ, Hong EK. Cordyceps militaris extract protects human dermal fibroblasts against oxidative stress-induced apoptosis and premature senescence. Nutrients. 2014 Sep 16;6(9):3711-26. doi: 10.3390/nu6093711. PMID: 25230212; PMCID: PMC4179184.

2. Choi EJ, Park B, Lee J, Kim J. Anti-atopic dermatitis properties of Cordyceps militaris on TNFα/IFNγ-stimulated HaCaT cells and experimentally induced atopic dermatitis in mice. Phys Act Nutr. 2020 Dec;24(4):7-14. doi: 10.20463/pan.2020.0022. Epub 2020 Dec 31. PMID: 33539689; PMCID: PMC7931639.

3. Yamaguchi Y, Kagota S, Nakamura K, Shinozuka K, Kunitomo M. Antioxidant activity of the extracts from fruiting bodies of cultured Cordyceps sinensis. Phytother Res. 2000 Dec;14(8):647-9. doi: 10.1002/1099-1573(200012)14:8<647::aid-ptr670>3.0.co;2-w. PMID: 11114006.

Suggested Dose 

3-5g daily

Mushroom

Reishi

Reishi (also known as Ganoderma lucidum) is a long-stalked polypore mushroom that has captured the attention of people for over two thousand years. The mushroom has much to offer with the bulk of research focused on its anti inflammatory benefits.

Clinical Trials

1. Rani P, Lal MR, Maheshwari U, Krishnan S. Antioxidant Potential of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) Cultivated on Artocarpus heterophyllus Sawdust Substrate in India. Int J Med Mushrooms. 2015;17(12):1171-7. doi: 10.1615/intjmedmushrooms.v17.i12.70. PMID: 26854104.

2. Kim JW, Kim HI, Kim JH, Kwon OC, Son ES, Lee CS, Park YJ. Effects of Ganodermanondiol, a New Melanogenesis Inhibitor from the Medicinal Mushroom Ganoderma lucidum. Int J Mol Sci. 2016 Oct 27;17(11):1798. doi: 10.3390/ijms17111798. PMID: 27801787; PMCID: PMC5133799.

Suggested Dose 

3-5g daily

Mushroom

Tremella (Snow Fungus)

Tremella, also known as the beauty mushroom, is a medicinal mushroom mostly known for its skin health and cognitive boosting benefits.

Clinical Trials

1. Chiang JH, Tsai FJ, Lin TH, Yang JS, Chiu YJ. Tremella fuciformis Inhibits Melanogenesis in B16F10 Cells and Promotes Migration of Human Fibroblasts and Keratinocytes. In Vivo. 2022 Mar-Apr;36(2):713-722. doi: 10.21873/invivo.12757. PMID: 35241526; PMCID: PMC8931924.

2. Yang D, Lian J, Wang L, Liu X, Wang Y, Zhao X, Zhang X, Hu W. The anti-fatigue and anti-anoxia effects of Tremella extract. Saudi J Biol Sci. 2019 Dec;26(8):2052-2056. doi: 10.1016/j.sjbs.2019.08.014. Epub 2019 Aug 14. PMID: 31889793; PMCID: PMC6923490.

Suggested Dose 

3-5g daily 

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